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RESEARCH OVERVIEW

The Translational Cancer Research Program in Oncology has been established at the Perkins in collaboration with Surgeons, Oncologists and Pathologists across several Perth hospitals. Our focus is on using state of the art omics technologies (including genomics, single cell sequencing, metabolomics, proteomics) to provide detailed molecular characterisation of individual cancers. In conjunction with this we have established better preclinical models to assess new cancer medicines. In particular, we have developed models that can more accurately evaluate new immunotherapy drugs.

This research will enable improved preclinical assessment of new drugs and combination therapies, leading to greater success rates for clinical trials and better outcomes for cancer patients. In addition, detailed genomic characterisation of cancers will facilitate the development of novel biomarkers needed to better monitor pharmacodynamics, predict response and resistance to specific drugs as well as enable better stratification of target populations.

Capabilities:
I. Perkins Cancer Biobank
II. Preclinical Cancer Models

Larissa Wintle

LATEST NEWS

Molecular machines stop cancer’s clock

Head of the laboratory for Synthetic Biology and Drug Discovery, Associate Professor Oliver Rackham, says cancer cells grow uncontrollably whereas normal cells limit their growth. “A normal cell grows for just the right amount of time that is required for us to develop and maintain our bodies. “They control their growth with…

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Stem cell reprogramming mystery clarified by new findings

In a study, published in Cell Stem Cell, researchers from the University of Western Australia, the Harry Perkins Institute of Medical Research, and Monash University describe key drivers of the process by which cells from mature tissues of the body, such as skin, can be deliberately converted into stem cells that…

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