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RESEARCH OVERVIEW

The Iron Metabolism Laboratory investigates the molecular mechanisms in normal iron metabolism and in the development of iron overload disorder hereditary haemochromatosis. We use transgenic murine models of iron overload and tumor cell lines to investigate cellular iron transport using radiolabelled tracers and expression of iron transporters and regulators of iron homeostasis. We have expertise in the area of molecular and cellular biology of iron including cell isolation and culture, iron transport, gene and protein expression, gene knockdown and immunohistochemistry. Our experience in these areas should be useful for participants in the ARC Metals in Medicine Network for the testing or screening of metals or metal complexes in biological systems.

LATEST NEWS

Boost for liver cancer patients with new $10.8 million world-class research centre

Patients with primary liver cancer will benefit from a new $10.8 million research centre established with a $5 million Cancer Research Trust grant and $5.8 million from Minderoo Foundation, Curtin University, The University of Western Australia, Harry Perkins Institute of Medical Research, the State Government and charitable organisations. Primary liver…

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Ground-breaking COVID-19 Vaccine Trial Underway in Perth: First Participants Dosed After Thousands Register

An unprecedented number of people signed up to help in the fight against COVID-19 with more than 4000 registering for a ground-breaking vaccine trial at the Perkins trials facility, Linear Clinical Research. The vaccine candidate S-Timer was one of the first protein-based COVID-19 vaccine candidates in the world to initiate…

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Improving treatment for severe leukaemia

Researchers from the Harry Perkins Institute of Medical Research have collaborated on a major project to help in the development of a new and improved way to treat the poor-prognosis blood cancer, acute myeloid leukaemia (AML). Dr Andrew Woo from the Perkins Laboratory for Cancer Medicine, participated in a major…

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