Perkins bowel cancer research revolves around investigating the impact of two key pathways in cancer progression to chemoresistant, metastatic disease – these are the SLIRP gene and oncogenic Notch signalling. Notch signalling has been identified as a major driver for the growth of a wide range of tumours, from leukaemia to breast cancer. Evidence is emerging to suggest that inhibiting Notch can suppress tumour growth. Clinical tests have been conducted on 25 different Notch inhibitors to determine if they can improve survival for cancer patients.
We focus on the clinical significance of the Notch signalling pathway in bowel cancer patients, investigating its effects on overall survival, risk of relapse following surgery and chemotherapy response rates. Ultimately, our research aims to provide information to guide therapeutic decisions that may improve patient prognosis, through personalised medicine for cancer patients.
We have found that SLIRP regulates hormones in the body, limiting the spread and resistance of cancers to chemotherapy. Furthermore, we found high tumour SLIRP levels were linked to improved survival of patients. This has led to us producing tangible outcomes such as developing new ways to repress oncogenic Notch signalling in bowel cancer using SLIRP.
Researchers are investigating the impact of two key pathways in cancer progression to chemoresistant, metastatic disease – these are the SLIRP gene and oncogenic Notch signalling, which can potentially suppress tumour growth