Professor Nigel Laing AO

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Scientific Head, Molecular Medicine

Professor Nigel Laing AO

Neurogenetic Disease

Scientific Head, Molecular Medicine

Professor Nigel Laing AO

Neurogenetic Disease

Profile

Professor Nigel Laing was born in Scotland and obtained both his BSc (Hons) in Pharmacology (1976) and PhD in Physiology (1979) from the University of Edinburgh. He spent one year as a Post-doc at the University of Oslo (1980) before coming to The University of Western Australia in January 1981.

His PhD and early career research was as a developmental neurobiologist investigating how motor neurons and muscles interact and determine each other's properties in the developing embryo. For a 12-month period, July 1987 to June 1988, Professor Laing re-trained in molecular genetics with Professor Teepu Siddique in Professor Allen Roses' Laboratory at Duke University North Carolina.

Returning to Western Australia in 1988, Professor Laing had the two tasks of developing molecular neurogenetic research and molecular neurogenetic diagnostics at The Australian Neuromuscular Research Institute and Royal Perth Hospital respectively. He successfully investigated Australian families with mostly dominantly inherited diseases, playing a role in identifying mutations in SOD1 as a cause of familial motor neuron disease, mutations in tropomyosin as the first known cause of nemaline myopathy, mutations in actin as a major cause of severe congenital myopathies of various types and mutations in myosin as the cause of "Laing" myopathy.

In 2015 Professor Laing was elected a Fellow of the Australian Academy of Health and Medical Sciences and was appointed an Officer of the Order of Australia in the General Division (AO). Professor Laing continues to hunt human disease genes, while now working towards developing possible treatments for some of the diseases he has identified, developing better diagnostics and implementing public health reproductive carrier screening programs to allow couples to know their chances of having children with severe genetic disorders.

Research interests

  • Reproductive carrier screening
  • Development of improved diagnostics
  • Development of treatments for genetic muscle diseases

Selected Publications

1. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O’Regan JP, Deng H-X, Rahmani Z, Krizus A, McKenna-Yasek D, Cayabyab A, Gaston S, Tanzi R, Halperin JJ, Herzfeldt B, Van den Berg R, Hung W-Y, Bird T, Deng G, Mulder DW, Smyth C, Laing NG, Soriano E, Pericak-Vance MA, Haines J, Rouleau GA, Gusella J, Horvitz HR, Brown Jr RH. 1993. Mutations in the gene encoding Cu/Zn superoxide dismutase are associated with familial amyotrophic lateral sclerosis. Nature362:59-62. [NCBI PubMed Entry] [IF 31.0]

2. Laing NG, Wilton SD, Akkari PA, Dorosz S, Boundy K, Kneebone C, Blumbergs P, White S, Watkins H, Love DR, Haan E. 1995. A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. Nature Genetics9:75-79. [NCBI PubMed Entry] [IF 26.5]

3. Nowak KJ, Wattanasirichaigoon D, Goebel HH, Wilce M, Pelin K, Donner K, Jacob RL, Hubner C, Oexle K, Anderson JR, Verity CM, North KN, Iannaccone ST, Muller CR, Nurnberg P, Muntoni F, Sewry C, Hughes I, Sutphen R, Lacson AG, Swoboda KJ, Vigneron J, Wallgren-Pettersson C, Beggs AH, Laing NG. 1999. Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy. Nature Genetics 23:208-12. [NCBI PubMed Entry] [IF 30.7]

4. Meredith C, Herrmann R, Parry C, Liyanage K, Dye DE, Durling HJ, Duff RM, Beckman K, De Visser M, Van Der Graaff MM, Hedera P, Fink JK, Petty EM, Lamont P, Fabian V, Bridges L, Voit T, Mastaglia FL, Laing NG. 2004. Mutations in the Slow Skeletal Muscle Fiber Myosin Heavy Chain Gene (MYH7) Cause Laing Early-Onset Distal Myopathy (MPD1). Am J Hum Genet 75:703-8. [NCBI PubMed Entry] [IF 11.6]

5. Nowak KJ, Ravenscroft G, Jackaman C, Filipovska A, Davies SM, Lim EM, Squire SE, Potter AC, Baker E, Clement S, Sewry CA, Fabian V, Crawford K, Lessard JL, Griffiths LM, Papadimitriou JM, Shen Y, Morahan G, Bakker AJ, Davies KE, Laing NG. 2009. Rescue of skeletal muscle {alpha}-actin-null mice by cardiac (fetal) {alpha}-actin. The Journal of cell biology 185:903-915. [NCBI PubMed Entry] [IF 9.6]

6. Ravenscroft G, Miyatake S, Lehtokari VL, Todd EJ, Vornanen P, Yau KS, Hayashi YK, Miyake N, Tsurusaki Y, Doi H, Saitsu H, Osaka H, Yamashita S, Ohya T, Sakamoto Y, Koshimizu E, Imamura S, Yamashita M, Ogata K, Shiina M, Bryson-Richardson RJ, Vaz R, Ceyhan O, Brownstein CA, Swanson LC, Monnot S, Romero NB, Amthor H, Kresoje N, Sivadorai P, Kiraly-Borri C, Haliloglu G, Talim B, Orhan D, Kale G, Charles AK, Fabian VA, Davis MR, Lammens M, Sewry CA, Manzur A, Muntoni F, Clarke NF, North KN, Bertini E, Nevo Y, Willichowski E, Silberg IE, Topaloglu H, Beggs AH, Allcock RJ, Nishino I, Wallgren-Pettersson C, Matsumoto N, Laing NG. 2013. Mutations in KLHL40 Are a Frequent Cause of Severe Autosomal-Recessive Nemaline Myopathy. American Journal of Human Genetics 93(1):6-18. [NCBI PubMed Entry] [IF 11.2]

7. Ravenscroft, G., F. Nolent, S. Rajagopalan, A. M. Meireles, K. J. Paavola, D. Gaillard, E. Alanio, M. Buckland, S. Arbuckle, M. Krivanek, J. Maluenda, S. Pannell, R. Gooding, R. W. Ong, R. J. Allcock, E. D. Carvalho, M. D. Carvalho, F. Kok, W. S. Talbot, J. Melki and N. G. Laing (2015). “Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita.” Am J Hum Genet 96(6): 955-961. [NCBI PubMed Entry] [IF 10.9]

8. Ong, R., D. Howting, A. Rea, H. Christian, P. Charman, C. Molster, G. Ravenscroft and N. G. Laing (2018). “Measuring the impact of genetic knowledge on intentions and attitudes of the community towards expanded preconception carrier screening.” J Med Genet 55(11): 744-752. https://www.ncbi.nlm.nih.gov/pubmed/30068663 [IF 5.7]

9. Delatycki, M. B., F. Alkuraya, A. Archibald, C. Castellani, M. Cornel, W. W. Grody, L. Henneman, A. S. Ioannides, E. Kirk, N. Laing, A. Lucassen, J. Massie, J. Schuurmans, M. K. Thong, I. van Langen, and J. Zlotogora. 2020. ‘International perspectives on the implementation of reproductive carrier screening’, Prenat Diagn, 40: 301-10. https://www.ncbi.nlm.nih.gov/pubmed/31774570

10. McNamara, E. L., R. L. Taylor, J. S. Clayton, H. Goullee, K. L. Dilworth, T. Pinos, A. Brull, I. E. Alexander, L. Lisowski, G. Ravenscroft, N. G. Laing, and K. J. Nowak. 2020. ‘Systemic AAV8-mediated delivery of a functional copy of muscle glycogen phosphorylase (Pygm) ameliorates disease in a murine model of McArdle disease’, Hum Mol Genet, 29: 20-30. https://www.ncbi.nlm.nih.gov/pubmed/31511858