Selected publications

  1. Kummer E, Leibundgut MA, Rackham O, Lee RG, Boehringer D, Filipovska A, Ban N. (2018) Unique features of mitochondrial translation initiation revealed by cryo-EM. Nature 560:263-267.
  2. Spåhr H, Chia T, Lingford JP, Siira SJ, Cohen SB, Filipovska A, Rackham O. (2018) Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins. Nature Communications 9(1):2212.
  3. Scott LH, Mathews JC, Flematti GR, Filipovska A, Rackham O. (2018) An artificial yeast genetic circuit enables deep mutational scanning of an antimicrobial resistance protein. ACS Synthetic Biology 7(8):1907-1917.
  4. Wallis CP, Filipovska A, Rackham O. (2018) Tighter ligand binding can compensate for impaired stability of an RNA-binding protein. ACS Chemical Biology 13(6):1499-1505.
  5. Wallis CP, Filipovska A, Rackham O. (2018) A modified yeast three-hybrid system enabling both positive and negative selections. Biotechnology Letters 40(7):1127-1134.
  6. Siira S, Spåhr H, Shearwood AJ, Ruzzenente B, Larsson NG, Rackham O, Filipovska A. (2017) LRPPRC-mediated folding of the mitochondrial transcriptome. Nature Communications 8(1):1532.
  7. Kuznetsova I, Siira SJ, Shearwood AJ, Ermer JA, Filipovska A, Rackham O. (2017) Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing. Nucleic Acids Research 45(9):5487-5500.
  8. Rackham O, Busch JD, Matic S, Siira S, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AJ, Richman TR, Stewart J, Mourier A, Milenkovic  D, Larsson NG, Filipovska A. (2016) Hierarchical RNA processing is rate limiting for mitochondrial ribosome assembly. Cell Reports 16(7):1874-90.
  9. Coquille S, Filipovska A, Chia T, Rajappa L, Lingford JP, Razif MF, Thore S, Rackham O. (2014) An artificial PPR scaffold for programmable RNA recognition. Nature Communications 5:5729.
  10. Filipovska A, Rackham O. (2013) Specialization from synthesis: how ribosome diversity can customize protein function. FEBS Letters 587(8):1189-1197.
  11. Thyer R, Filipovska A, Rackham O. (2013) Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation. Journal of the American Chemical Society (JACS) 135(1):2-5.
  12. Filipovska A, Rackham O. (2012) Modular recognition of nucleic acids by PUF, TALE and PPR proteins. Molecular Biosystems 8(3):699-708.
  13. Rackham O, Shearwood AM, Mercer TR, Davies SM, Mattick JS, Filipovska A. (2011) Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins. RNA 17(12):2085-93.
  14. Mercer TR, Neph S, Dinger ME, Crawford J, Smith MA, Shearwood AM, Haugen E, Bracken CP, Rackham O, Stamatoyannopoulos JA, Filipovska A, Mattick JS. (2011) The human mitochondrial transcriptome. Cell 146(4):645-58.
  15. Filipovska A, Razif MF, Nygård KK, Rackham O. (2011) A universal code for RNA recognition by PUF proteins. Nature Chemical Biology 7(7):425-427.
  16. Filipovska A and Rackham O. (2008) Building a parallel metabolism within the cell. ACS Chemical Biology 3(1):51-63.
  17. Rackham O, Wang K, Chin JW. (2006) Functional epitopes at the ribosome subunit interface. Nature Chemical Biology 2(5):254-258.
  18. Rackham O, Chin JW. (2005) Cellular logic with orthogonal ribosomes. Journal of the American Chemical Society (JACS) 127(50):17584-17585.
  19. Rackham O, Chin JW. (2005) A network of orthogonal ribosome•mRNA pairs. Nature Chemical Biology 1(3):159-166.
  20. Rackham O, Brown CM. (2004) Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs. EMBO Journal 23(16):3346-3355.
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