Brain growth and disease

Selected publications

  1. Haas MA, Ngo L, Li SS, Schleich S, Qu Z, Vanyai HK, Cullen HD, Cardona-Alberich A, Gladwyn-Ng IE, Pagnamenta AT, Taylor JC, Stewart H, Kini U, Duncan KE, Teleman AA, Keays DA, Heng JI. De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to defective mRNA translation re-initiation. 2016 Cell Reports, In Press [IF=8.35]
  2. Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI. Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity, and increased Parvalbumin-positive cortical interneuron density. Molecular Autism. 2016, in press. [IF=5.4] [NCBI PubMed Entry]
  3. Gladwyn-Ng, IE, Huang, L, Ngo L, Li SS, Qu Z, Vanyai HK, Cullen HD, Davis JM, Heng JI. Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. Neural Development. 2016 Mar 11;11(1):7. doi: 10.1186/s13064-016-0062-1. [IF=3.72] [NCBI PubMed Entry]
  4. Harris L., Zalucki O., Piper M, Heng JI. Insights into the biology and therapeutic applications of neural stem cells. Stem Cells International. 2016, doi:10.1155/2016/9745315. [IF=2.81] [Stem Cells International]
  5. Hemming IA, Forrest AR, Shipman P, Woodward KJ, Walsh P, Ravine DG, Heng JI. Reinforcing the association between distal 1q CNVs and structural brain disorder: A case of a complex 1q43-q44 CNV and a review of the literature. American Journal of Medical Genetics Part B Neuropsychiatric Genetics. 2016 Feb 7. doi: 10.1002/ajmg.b.32427. [IF=2.3] [NCBI PubMed Entry]
  6. Sim J, Scerri T, Fanjul Fernandez M, Risely J, Gillies G, Pope K, van Roozendaal H, Heng JI, Mandelstam S, McGillivray G, McGregor D, Kannan L, Maixner W, Harvey SA, Amor D, Delatycki M, Crino P, Bahlo M, Lockhart P, Leventer R. Familial cortical dysplasia caused by mutation in the mTOR regulator NPRL3. Annals of Neurology. 2015 accepted [IF= 9.97] [NCBI PubMed Entry]
  7. Xu X-J, Jaehne EJ, Greenberg Z, McCarthy P, Saleh E, Parish CL, Heng JI, Haas M, Baune BT, Ratnayke U, Buuse M, Lopez AF, Ramshaw HS, Schwarz Q. Deficiency of 14-3-3ζ causes behavioural and anatomical defects associated with neurodevelopmental disorders. Scientific Reports. 2015 Jul 24;5:12434. doi: 10.1038/srep12434 [IF=5.078] 
  8. Gladwyn-Ng L, Li SS, Qu Z, Davis JM, Ngo L, Haas MA, Singer JD, Heng JI. Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex. Neural Development. 2015 2015 Mar 31;10:9. doi: 10.1186/s13064-015-0032-z. [IF=3.72] Manuscript is “Highly Accessed”. [NCBI PubMed Entry]
  9. Ngo L, Haas M, Qu Z, Li SS, Zenker J, Teng KS-L, Gunnersen JM, Breuss M, Habgood M, Keays DA, Heng JI. TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Human Molecular Genetics. 2014 May 15. pii: ddu238. [NCBI PubMed Entry]
  10. Heng JI*, Qu Z, Ohtaka-Maruyama C, Okado H, Kasai M, Castro DS, Guillemot F, Tan S-S. The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cortical development. Cerebral Cortex. 2013. doi: 10.1093/cercor/bht277. Epub 2013 Oct 1 (*denotes corresponding author) [NCBI PubMed Entry]
  11. Ohtaka-Maruyama C, Hirai S, Miwa A, Heng JI, Shitara H, Ishii R, Taya C, Kawano H, Kasai M, Nakajima K, Okado H. RP58 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Cerebral Cortex. Cell Reports. 2013 Feb 21;3(2):458-71. doi: 10.1016/j.celrep.2013.01.012. Epub 2013 Feb 7. [NCBI PubMed Entry]
  12. Haas M, Qu Z, Kim TH, Vargas E, Campbell K, Petrou S, Tan S-S, Reid CA, Heng JI. Perturbations in cortical development and seizure susceptibility arising from prenatal exposure to benzodiazepines in mice. European Journal of Neuroscience. 2013 May;37(10):1584-93. doi: 10.1111/ejn.12167. [NCBI PubMed Entry]
  13. Heng JI*, Breuss M*, Poirier K, Tian GL, Jaglin JH, Qu Z, Braun A, Gstrein T, Ngo L, Haas M, Bahi-Buisson N, Moutard M-L, Passemard S, Verloes A, Gressens P, Xie YL, Robson KJH, Rani DS, Thangaraj K, Clausen T, Chelly J, Cowan NJ, Keays DA. Mutations in the b-tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities. Cell Reports. 2012 Dec 27;2(6):1554-62. (*denotes equal authorship) [NCBI PubMed Entry]
  14. Kim TH, Richards K, Heng JI, Petrou S, Reid CA.  Two lines of transgenic mice expressing cre recombinase exhibit increased seizure susceptibility. Epilepsia. 2012 Nov 26. doi:pii: S0920-1211(12)00311-7. [NCBI PubMed Entry]
  15. Bogoyevitch MA, Yeap YY, Qu Z, Ngoei KR, Yip YY, Zhao TT, Heng JI, Ng DC (2012) WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression. Journal of Cell Science. 2012 Nov 1;125(Pt 21):5096-109. [NCBI PubMed Entry]
  16. Alfano C, Viola L, Heng JI, Pirozzi M, Clarkson M, Flore G, De Maio A, Schedl A, Guillemot F, Studer M. (2011) COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression. Development. Nov;138(21):4685-97. [NCBI PubMed Entry]
  17. Pacary E, Heng JI, Azzarelli R, Riou P, Castro DS, Lebel-Potter M, Parras C, Bell DM, Ridley AJ, Parsons M, Guillemot F (2011) Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signalling.  Neuron, 24;69(6):1069-84. [NCBI PubMed Entry]
  18. Heng JI*, Chariot A, Nguyen L* (2010) Molecular layers underlying cytoskeletal remodelling during cortical development.  Trends in Neurosciences, 33(1):38-47. (*corresponding authors) [NCBI PubMed Entry]
  19. Mérot Y, Rétaux S, Heng JI* (2009) Molecular mechanisms of projection neuron production and maturation in the developing cerebral cortex. Seminars in Cell and Developmental Biology, 20(6):726-34. (*corresponding author) [NCBI PubMed Entry]
  20. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F. (2008) Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature, 455(7209):114-8. [NCBI PubMed Entry]
  21. Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A (2008) The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nature Cell Biology, 10(6):643-53. [NCBI PubMed Entry]
  22. Heng JI, Moonen G, Nguyen L (2007) Neurotransmitters regulate cell migration in the telencephalon. European Journal of Neuroscience, 26(3):537-46. [NCBI PubMed Entry]
  23. Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F (2006) p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes & Development, 20(11):1511-24. [NCBI PubMed Entry]
  24. Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE (2006) Coupling of cell migration with neurogenesis by proneural bHLH factors. Proceedings of the National Academy of Sciences USA, 103(5): 1319-24. [NCBI PubMed Entry]
  25. Hand R, Bortone D, Mattar P, Nguyen L, Heng JI, Guerrier S, Boutt E, Peters E, Barnes AP, Parras C, Schuurmans C, Guillemot F, Polleux F. (2005) Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron, 48(1):45-62. [NCBI PubMed Entry]
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