Vascular biology and stromal targetting

Selected publications

  1. Holobotovskyy V, Chong JS, Burchell J, He B, Phillips M, Leader L, Murphy TV, Sandow SL, McKitrick D , Charles A, Tare M, Arnolda L, Ganss R. Regulator of G protein signaling 5 is a determiant of gestational hypertension and preeclampsia. 2015. Sci Transl Med 7, 290ra88. [Sci Transl Med]

  2. Holobotovskyy V, Manzur M, Burchell J, Bolitho E, Tare M, Viola H, Hool L, Arnolda L, McKitrick D , Ganss R. Regulator of G protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling. 2013. Circulation Res. 112 (5):781-91. [NCBI PubMed Entry]

  3. Johansson A, Hamzah J, Payne CJ, Ganss R. 2012. Tumor-targeted TNFα Stabilizes Tumor Vessels and Enhances Active Immunotherapy. PNAS 109 (20):7841-6. [NCBI PubMed Entry]

  4. Hamzah J, Altin JG, Herringson T, Parish CR, Hämmerling GJ, O'Donoghue H, Ganss R. 2009. Targeted delivery of TRL9 ligands activates spontaneous anti-tumor immunity in an autochthonous tumor model. Journal of Immunology 183(2):1091-8. [NCBI PubMed Entry]

  5. Manzur M, Hamzah J, Ganss R. 2009. Modulation of G protein Signaling Normalizes Tumor Vessels. Cancer Research 69(2):396-9 [NCBI PubMed Entry]

  6. Hamzah J, Jugold M, Kiessling F, Rigby P, Manzur M, Marti HH, Rabie T, Kaden S, Gröne HJ, Hämmerling GJ, Arnold B, Ganss R. 2008. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453(7193):410-4. [NCBI PubMed Entry] [Nature Website]

  7. Hamzah J, Nelson D, Moldenhauer G, Arnold B, Hämmerling GJ, Ganss R. 2008. Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice. The Journal of Clinical Investigation 118(5):1691-9. [NCBI PubMed Entry]

  8. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. 2008. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13(3):206-20. [NCBI PubMed Entry]

  9. Spring H, Schüler T, Arnold B, Hämmerling GJ, Ganss R. 2005. Chemokines direct endothelial progenitors into tumor neovessels. Proceedings of the National Academy of Sciences of the USA 102(50):18111-6. [NCBI PubMed Entry]

  10. Berger M, Bergers G, Arnold B, Hämmerling GJ, Ganss R. 2005. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood 105(3):1094-101. [NCBI PubMed Entry]

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