Vascular biology and stromal targeting

Research overview
Changes in the tissue microenvironment, which is also called stroma, play a crucial role in disease progression. Our research program aims to understand how stromal cells are remodelled, and the extent to which stroma regulates inflammatory diseases such as cancer and atherosclerosis. We specifically target abnormal stromal features for early disease detection and monitoring of progressive disease.

In addition, we have pioneered the field by demonstrating that stromal remodelling rather than destruction enhances drug and immune cell uptake into pathological lesions. Our novel therapeutic strategies involve disruption and re-programming of signalling networks between multiple stromal components to break the vicious cycle of disease progression and relapse.

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