Cell signalling


Current research projects
Leukaemia and cancer cells have altered biochemical properties resulting in their high rate of growth, capacity to evade the immune system and ability to invade/metastasis. One of the hallmarks of cancer is augmented activity of enzymes called tyrosine kinases including members of the Src family. One Src family member called Lyn has important roles in leukaemia (AML, CML, CLL) and solid cancer (prostate, breast, and colon).

This research group has identified several new molecules and pathways that are controlled by Lyn as well as mechanisms that control the activity/protein level of Lyn. These pathways/regulatory mechanisms mediate cancer cell activities, including survival, proliferation, and migration/metastasis. These may allow us to develop novel diagnostic approaches or therapeutics for cancer treatment and control.

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