Cell signalling


Research overview

Protein tyrosine kinases are enzymes that functions as on/off switches that control many cellular functions. The Cell Signalling team investigates protein tyrosine kinases (PTK), which are divided into two classes – receptor and non-receptor PTKs. Both the receptor and non-receptor PTKs are essential for cellular signalling processes that regulate cell growth, differentiation, migration and metabolism. We now know that PTKs are involved in the development of many types of cancer and leukaemia and in particular they are associated with the likelihood that a tumour will spread. Recent advances in the development of drugs that inhibit PTK have resulted in great success in treating specific leukaemias and tumours.

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