Perkins Seminar: Professor Phil Darcy

Event Date and Time:
Thursday 22nd August, 2019 @ 12:00pm - 1:00pm

Venue:
McCusker Auditorium, Harry Perkins Institute of Medical Research, Nedlands

Professor Phil Darcy is currently a NHMRC Principal Research Fellow and Group Leader at the Peter MacCallum Cancer Centre. Phil has pioneered the development of chimeric antigen receptor (CAR) T cell therapy over the past 20 years in mouse models of cancer and shown that adoptive transfer of CAR modified mouse and human T cells could effectively eradicate cancer in mice. He has established a number of important collaborations with other immunotherapy groups and clinicians that resulted in a Phase I clinical trial using CAR T cells targeting the Lewis Y (LeY) antigen being undertaken at the Peter MacCallum Cancer Centre in patients with acute myeloid leukaemia that represented a first trial of this kind in Australia.

A second CAR T cell trial supported by Juno/Celgene is ongoing in patients with LeY+ solid cancers. More recently, his studies have involved combining CAR T cells with other immune based therapies including checkpoint inhibitors which is showing tremendous promise in preclinical mouse models and patients.

Phil has served on the editorial board of several journals including Cancer Research and served on numerous grant panels for NHMRC, NBCF and CCV. He has published over 150 papers in his field, holds several patents and has received tremendous support from both national and international funding bodies and industry. He will play a major role in the future for establishing the Peter Mac as the new “Centre of Excellence” for CAR T cell therapy in the effective treatment of cancer patients.

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