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Each Thursday at noon, the Perkins hosts a seminar presented by a medical research expert on health and disease.

Join us in the McCusker Auditorium as this week’s expert, Professor Pamela Ohashi, presents “Insights in immune regulation from the tumour microenvironment”.

Professor Pam Ohashi is the Director of the Tumor Immunotherapy Program at the Princess Margaret Cancer Centre in Toronto. She is also the Co- Director of the Campbell Family Institute for Breast Cancer Research, a Senior Scientist at the Princess Margaret Cancer Centre, and Professor in the Departments of Medical Biophysics and Immunology at the University of Toronto. Her research interests are adaptive immunity, autoimmunity, cancer immunology and cell signalling.

Her lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerised in vivo, using a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. Her group examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses. Her interests have expanded to establishing an immune therapy platform, the group having developed the ability to grow tumour infiltrating T cells and to characterise their properties. They have coordinated clinical trials, and are building towards a comprehensive program in immune therapy.

Prof Ohashi received her PhD from the University of Toronto with Dr Tak Mak, and did her post-doctoral training at the University of Zurich with the Nobel Laureate Dr Rolf Zinkernagel, and Dr Hans Hengartner. Prof Ohashi has received a number of prestigious awards and honors including the American Association of Immunologists (AAI) Pharmingen Investigator Award, the National Cancer Institute of Canada’s William E. Rawls Award, The Canadian Society of Immunology’s Investigator Award as well as a Tier 1 Canada Research Chair. She is an elected member of the Royal Society of Canada.


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