Dr Lazarus is currently a postdoc at the University of Cambridge studying novel drivers of two tumours of unmet need, lung squamous cancer and triple negative breast cancer. His PhD training with Drs Ashwini Chand and Colin Clyne focused on the role of LRH-1 in mammary gland development and cancer (2010-2014). He then studied how Kupffer cells promoted liver progenitor cell initiation and maintenance with Drs Caryn Elsegood and George Yeoh (2014 – 2015).
In Feb 2015, he started his postdoctoral training with Dr Walid Khaled where he uses mouse models, ex vivo models, lineage tracing and single cell genomic analysis to understand how early tumour initiating events in single cells lead to the heterogeneous nature of cancer which can pave the way for better therapies. Here he uncovered novel and distinct roles for the transcriptional regulator BCL11A in LUSC and TNBC.
Building on his PhD and postdoctoral expertise, Dr Lazarus aims to set up his laboratory with the purpose of studying the immune system in lung disease and cancer.