Benjamin Dwyer is a Postdoctoral Research Fellow at the MRC Centre for Regenerative Medicine at the University of Edinburgh in the laboratory of Professor Stuart Forbes. His background is in defining progenitor cells of the liver and pancreas, in which he obtained his PhD from the University of Western Australia in 2015. He has since worked with A/Prof Nina Tirnitz-Parker at Curtin University, assessing signals controlling cellular crosstalk between components of the liver inflammatory, fibrogenic and regenerative responses to chronic liver injury, prior to joining the Forbes team in Edinburgh.
He is currently involved in a first-in-human cell therapy clinical trial to treat liver cirrhosis patients with autologous macrophages, assessing serum biomarkers and circulating immune cell populations to ascertain cell product safety and efficacy. He is also a part of a research and development team that develops GMP-compliant methods to enhance the therapeutic potential of macrophages for treating liver disease.
In addition to clinically-focussed research, he is also defining novel interactions between malignant epithelial cells and stromal cells in cholangiocarcinoma, with emphasis on signals directing macrophage trafficking and patterning in the tumour niche, and how these pathways might be interrupted for therapeutic benefit.