Perkins Seminar: Associate Professor Kaylene Simpson

Event Date and Time:
Thursday 8th August, 2019 @ 12:00pm - 1:00pm

Venue:
McCusker Auditorium, Harry Perkins Institute of Medical Research, Nedlands

Associate Professor Kaylene Simpson Heads the Victorian Centre for Functional Genomics (VCFG) at Peter MacCallum Cancer Centre. The VCFG enables researchers Australia-wide to perform unbiased gene discovery using high throughput gene targeting approaches such as CRISPR/cas9 and RNA interference, quantitative Reverse Phase Protein Arrays, compound screening and high content imaging. She leads a highly experienced team who actively engage with researchers to help drive their research projects to fruition. She has a wealth of experience in assay development, data interpretation and analysis and overall guidance in the area of functional genomics and contributes intellectually to all projects and technology initiatives within the institute.

Facility: The (VCFG) enables biomedical researchers Australia-wide the ability to perform novel discovery-based high throughput screens across a number of complementary platforms. The VCFG facilitates functional interrogation of all genes in the genome, or selected boutique collections using CRISPR/cas9, small interfering RNA (siRNA), micro RNA (miRNA), long non-coding RNA (lncRNA) and short hairpin RNA (shRNA) approaches. The VCFG enables large and small scale drug screens using commercially available compounds or BYO compounds. The VCFG has extensive experience in quantitative high content phenotypic screening and has developed sophisticated analytical pipelines for data analysis.

The VCFG has established an Australia-first, Reverse Phase Protein Array platform, another high throughput discovery technology that allows for rapid quantitation of the expression of native and phospho-specific protein isoforms in very small sample populations. Most recently the VCFG has installed the first 3D bioprinting instrument from Australian company Inventia Life Science. The Rastrum can embed cells from cell lines, immune cells and patient tissues into a matrix scaffold that can support 3D growth and drug screening in high throughput. This technology will dramatically accelerate drug discovery.

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