Dr Stephen Macdonald

Stephen Macdonald

Email: stephen.macdonald@health.wa.gov.au

Stephen Macdonald undertook specialist training in Emergency Medicine in Western Australia. He obtained his Fellowship of the Australasian College for Emergency Medicine in 2010.

In 2011 Dr Macdonald was apointed as a clinical academic at the University of Western Australia, based at Armadale Health Service where he established a productive research unit. In 2015 he moved to Royal Perth Hospital and divides his time between research and clinical work in the Emergency Department.

Dr Macdonald has successfully completed a number of research studies on topics such as chest pain and heart failure. the main theme of his current research work is sepsis. He is leading a national multicentre pilot trial comparing fluid sparing versus fluid liberal resuscitation in septic shock (ACTRN12616000006448), and is completing a PhD investigating endothelial cell activation biomarkers in sepsrs pathogenesis and diagnosis.  

Dr Macdonald is a reviewer for several international journals and grant awarding bodies including the Queensland Emergency Medicine Research Foundation and the National Health and Medicinal Research Council. He is a section editor Emergency Medicine Australia. 


1992 BSc (Hons) in Pharmacology, University of Edinburgh, UK
1994 MB ChB, University of Edinburgh, UK
1997 MRCP, Royal Colleges of Physicians, UK
2002 MRCGP (Distinction), Royal College of General Practitioners, UK
2004 Diploma in Child Health, University of Western Australia, Australia
2010 FACEM - Fellow of Australasian College for Emergency Medicine
2014 FRCP (Edin) - Royal College of Physicians of Edinburgh

Grants Awarded

Keijzers G, Macdonald SPJ, Kinnear F, Taylor D McD, Arendts G, Fatovich DM, Brown SGA, Asha S, Vlad I, McCutcheon D. Restricted Fluid Resuscitation in Sepsis associated Hypotension (REFRESH) trial. Queensland Emergency Medicine Foundation, 2016-17

Macdonald SPJ, Stone SF, Brown SGA. Biomarkers to predict organ failure in early sepsis. Australiasian College of Emergency Foundation New Investigator Award, 2014-15

Macdonald SPJ, Chu K, Brown AFT, Brown SGA, Fatovitch DA, Arendts GA, Keijzers G, Kinnear F, Cullen L, Greenslade J, Lukin W, Williams J. Establishment of an Emergency Medicine Research Collaboration. University of Queensland / University of Western Australia Bilateral Research Collaboration Award, 2013-15

Top Publications in the last 5 years

Idrees M, Macdonald SPJ, Kodali, K. Sepsis Early Alert Tool: early recognition and timely management in the Emergency Department. Emerg Med Australas 2016, Published online 5 May doi: 10.1111/1742-6723.12581 [NCBI PubMed Entry]

Taylor D McD, Fatovich DM, Finucci, DP, Furyk, J, Jin S, Keijzers G, Macdonald SPJ, Mitenko HMA, Richardson, JR, Ting JYS, Thom ON, Ugoni AM, Hughes JA, Bost N, Ward ML, Gibbs CR, Macdonald E, Chalkley DR. Best-practice pain management in the emergency department; A cluster-randomised, controlled intervention trial. Emerg Med Australas 2015;27:549-557 [NCBI PubMed Entry]

Macdonald SPJ, Brown SGA. Near-infrared spectroscopy in the assessment of suspected sepsis in the emergency department Emerg Med J 2015; 32:404-408. [NCBI PubMed Entry]

Barrett OSH, Macdonald SPJ, Playford DA. Near-infrared spectroscopy based microcirculatory assessment in acute atrial fibrillation. Anaesth Intensive Care 2015; 48:105-110. http://www.ncbi.nlm.nih.gov/pubmed/25579297

Macdonald SPJ, Arendts G, Fatovich DM, Brown SGA. Comparison of PIRO, SOFA and MEDS scores for predicting mortality in ED patients with severe sepsis and septic shock. Acad Emerg Med 2014; 21:1257-1263. http://www.ncbi.nlm.nih.gov/pubmed/25377403

Macdonald SPJ, Stone SF, Neil CL, van Eeden PV, Fatovich DM, Arendts GA, Brown SGA Sustained elevation of Resistin, NGAL and IL-8 are associated with severe sepsis/septic shock in the Emergency Department. PLoSONE 2014; 9(10):e110678 http://www.ncbi.nlm.nih.gov/pubmed/25343379

Isbister GK, Page CB, Buckley NA, Fatovich DM, Pascu O, Macdonald SPJ, Calver LA, Brown SGA. Randomised controlled trial of intravenous antivenoms versus placebo for latrodectism: the second redback antivenoms evaluation (RAVE-II) study. Ann Emerg Med 2014; 64:620-628.e2. http://www.ncbi.nlm.nih.gov/pubmed/24999282

Brown SGA, Ball EL, Macdonald SPJ, Wright C, Taylor DM. Spontaneous pneumothorax: a multicentre retrospective analysis of emergency treatment, complications and outcomes. Intern Med J 2014; 44:450-457. http://www.ncbi.nlm.nih.gov/pubmed/24612237

Macdonald SPJ, Nagree Y, Fatovich DM, Brown SGA Modified TIMI risk score cannot be used to identify low risk chest pain in the Emergency Department: a multicentre validation study Emerg Med J 2014; 31:281-285. [NCBI PubMed Entry]

Huddle N, Arendts G, Macdonald SPJ, Fatovich DM, Brown SGA. Is comorbid status the best predictor of one-year mortality in patients with severe sepsis and sepsis with shock? Anaesth Intensive Care 2013; 41:482-489. [NCBI PubMed Entry]

Macdonald SPJ, Brown SGA. Near-infrared spectroscopy in the assessment of suspected sepsis in the emergency department (Review) Emerg Med J Published Online First: 23 October 2013 doi 10.1136/emermed-2013-202956. [NCBI PubMed Entry]

Macdonald SPJ, Nagree Y, Fatovich DM, Phillips M, Brown SGA. Serial multiple biomarkers in the assessment of suspected acute coronary syndrome: Multiple Infarct Markers in Chest pain (MIMIC) study. Emergency Medicine Journal 2013; 30:149-154. [NCBI PubMed Entry]

Chung K, Playford D, Macdonald SPJ. Improving stress testing compliance following chest pain presentations to the Emergency Department. Emergency Medicine Australasia 2012; 24:518-524. [NCBI PubMed Entry]

Macdonald SPJ, Arendts G, Nagree Y, Xu X-F. Neutrophil gelatinase-associated lipocalin (NGAL) predicts renal injury in acute decompensated cardiac failure; a prospective observational study. BMC Cardiovascular Disorders 2012; 12:8. [NCBI PubMed Entry]

Macdonald SPJ, Nagree Y, Fatovich DM, Flavell HL, Loutsky F. Comparison of two clinical scoring systems for emergency department risk stratification of suspected acute coronary syndrome. Emergency Medicine Australasia 2011; 23:717-725. [NCBI PubMed Entry]

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