Associate Professor Shelley Stone


T: + 61 8 9224 0356Shelley Stone
E: shelley.stone@uwa.edu.au


Profile
Associate Professor Shelley Stone was awarded her PhD (Distinction) from the University of Western Australia (UWA) in 2004 for her work investigating the immunopathogenesis of Immune Restoration Disease in HIV patients receiving antiretroviral therapy under the supervision of Prof Martyn French and A/Prof Patricia Price. After two years postdoctoral experience at the Center for AIDS Research at Case Western Reserve University, Cleveland, Ohio, USA, she returned to Australia to join the Centre for Clinical Research in Emergency Medicine, changing her research focus from HIV to immunological mechanisms of critical illness.

Research projects
The Critical Illness and Shock Study (CISS) - this is a prospective observational study of patients presenting to the Emergency Department (ED) with critical illnesses or injuries that compromise the cardiovascular and/or respiratory systems. Clinical and laboratory data will be used to better define and correlate clinical features, aetiology, pathophysiology and outcomes. The analysis of plasma, serum, leukocytes and DNA samples will enable us to investigate mechanisms of disease and novel biomarkers that may eventually facilitate improved diagnosis and therapy.

Qualifications

1999 BSc (Hons, first class) - University of Western Australia, Australia
2004 PhD (Distinction) - University of Western Australia, Australia
Thesis Title: "Immune reconstitution and immune restoration disease in human immunodeficiency virus infected individuals receiving highly active antiretroviral therapy"

Research Interests
Immune mechanisms of critical illness, including anaphylaxis, head trauma, stroke and sepsis.

Scientific Involvement
Australasian Society for Immunology - Member 1999-2004, 2007 onwards.

Media Coverage
Australian Microscopy & Microanalysis Research Facility (AMMRF) March 2010 

Major Grants Awarded

2012 US Food Allergy and Anaphylaxis Network Research Grant. Leukocyte signalling during human anaphylaxis; 2012-2013 US$260,000. Brown SG, Stone SF.
2011 Neurotrauma Research Program. Leukocyte cell signaling after traumatic brain injury: correlation with clinical outcomes; 2011:$105,789, 2012:$122,655. Brown SG, Stone SF, Webb S, Henry N, Rao S, Fatovich D, Arendts G.
2010 Edith Cowan University Early Career Researcher Grant. Defining the mechanisms behind hypersensitivity reactions to Australian Snake Antivenom Preparations; $24,822. Alner T, Stone SF, Brown SG.
2010 Raine Medical Research Foundation Priming Grant. Molecular mechanisms of human anaphylaxis: Role of Interleukin-10. $90,000. Stone SF.
2010 Royal Perth Hospital Medical Research Foundation (Research Grant). Tools for investigating the mechanisms of severe allergic reactions: Culturing mast cells from human peripheral blood progenitor cells. $13,900. Stone SF.
2009 Royal Perth Hospital Medical Research Foundation (Infrastructure Grant). Establishing a Centre for Clinical Research in Emergency Medicine. 2009: $126,412, 2010: $66,072. Brown SGA, Stone SF, Arendts G, Fatovich DM.
2008 University of Western Australia Research Grant. Development of assays to monitor changes in IgE-facilitated mast cell degranulation and antigen presentation during immunotherapy for severe venom allergy. $29,600. Stone SF.
2008 Fremantle Hospital Medical Research Foundation Grant. Developing a standardised venom extract from WA bull ants for therapeutic use. $14,490. Stone SF, Aulfrey S, Brown SGA.

Publications

  1. Stone SF, Price P, Brochier J, French MA. 2001. Plasma bioavailable interleukin-6 is elevated in human immunodeficiency virus-infected patients who experience herpesvirus-associated immune restoration disease after start of highly active antiretroviral therapy. The Journal of Infectious Diseases 184(8):1073-7. [NCBI PubMed Entry]
  2. Stone SF, Price P, Tay-Kearney M, French MA. 2002. Cytomegalovirus (CMV) Retinitis Immune Restoration Disease occurs during Highly Active Antiretroviral Therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment. The Journal of Infectious Diseases 185(12):1813-7. [NCBI PubMed Entry]
  3. Stone SF, Lee S, Keane NM, Price P, French MA. 2002. Association of increased Hepatitic C Virus (HCV)-specific IgG and soluble CD26 dipeptidyl peptodase IV enzyme activity with hepatotoxicity after highly active antiretroviral therapy in human immunodeficiency virus/HCV-co-infected patients. The Journal of Infectious Diseases 186(10):1498-502. [NCBI PubMed Entry]
  4. French MA, Price P, Stone SF. 2004. Immune restoration disease after antiretroviral therapy. AIDS 18(12):1615-27. [NCBI PubMed Entry]
  5. Stone SF, Price P, Khan N, Moss PA, French MA. 2005. HIV patients with nadir CD4+ T-cell counts <50/µl have high frequencies of CD8+ T-cells specific for Immediate Early Protein-1 of cytomegalovirus after fours years on HAART. AIDS 19(6):555-62. [NCBI PubMed Entry]
  6. Stone SF, Cotterell C, Isbister GK, Holdgate A, Brown SGA. 2009. Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions. The Journal of Allergy and Clinical Immunology 124(4):786-92. [NCBI PubMed Entry] [IF 9.77]
  7. Brown SGA, Stone SF. 2011. Laboratory diagnosis of acute anaphylaxis. Clinical and Experimental Allergy 41(12):1660-2. [NCBI PubMed Entry]
  8. Arendts G, Stone SF, Fatovich DM, van Eeden PE, MacDonald E, Brown SGA. 2012. Critical illness in the emergency department - lessons learnt from the first 12 months of enrolments in the Critical Illness and Shock Study (CISS). Emergency Medicine Australiasia 24(1):31-6. [NCBI PubMed Entry]
  9. Stone SF, Brown SGA. 2012. Mediators released during human anaphylaxis. Current Allergy and Asthma Reports 12(1):33-41. [NCBI PubMed Entry]
  10. Brown SG, Wiese MD, van Eeden P, Stone SF, Chuter CL, Gunner J, Wanandy T, Phillips M, Heddle RJ. 2012. Ultrarush versus semirush initiation of insect venom immunotherapy: A randomized controlled trial. The Journal of Allergy and Clinical Immunology 130(1):162-8. [NCBI PubMed Entry]
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