Stem cell reprogramming mystery clarified by new findings
By leafcutter_admin | Cells, Disease Area, Epigenetics and Genomics Laboratory, Lab, Molecular Medicine, News & Events, Research, Research AreaIn a study, published in Cell Stem Cell, researchers from the University of Western Australia, the Harry Perkins Institute of Medical Research, and Monash University describe key drivers of the process…
Faulty gene linked to obesity in adults
By leafcutter_admin | Cardiovascular Disease, Disease Area, Lab, Mitochondrial Medicine and Biology, Molecular Medicine, News & Events, Research, Research AreaThe study, published in Science Advances, found that reduced function of a gene that impacts the breakdown of fats resulted in adult-onset obesity and fatty liver. Head of the Mitochondrial…
New way to examine how medicines act on cells
By leafcutter_admin | Cancer, Chronic Kidney Disease, Disease Area, Lab, Molecular Endocrinology and Pharmacology, Molecular Medicine, News & Events, Research, Research AreaUsing a genome editing technique called CRISPR/Cas9, the researchers attached a super-bright glowing molecule, derived from deep sea shrimp, to specific molecules important for signalling in cancer cells, ‘receptors’. Receptors…
Sudden infant cardiac death explained by gene mutation
By leafcutter_admin | Lab, Molecular Medicine, Neurogenetic Diseases, News & Events, Research, Research AreaLast year the Perkins Neurogenetic Diseases Laboratory received DNA from a family in Scotland whose four-month-old baby had tragically suffered a cardiac arrest and died. With the family’s permission, their doctor sent…
Perkins researchers find essential gene for healthy hearts
By leafcutter_admin | Disease Area, Heart, Lab, Mitochondrial Medicine and Biology, Molecular Medicine, News & Events, Research, Research Area, Synthetic Biology and Drug DiscoveryProfessor Aleksandra Filipovska and her team from the Perkins Mitochondrial Medicine and Biology Laboratory in collaboration with Professor Oliver Rackham and Professor Nils Göran Larsson and his team from the Max Planck Institute for Biology…
Perkins researchers decipher world-first muscle disorder cases
By leafcutter_admin | Disease Area, Genes, Lab, Molecular Medicine, Muscles, Neurogenetic Diseases, News & Events, Research, Research AreaDuring their investigation the multi-national team of researchers studied a muscle protein that is strongly influenced by calcium. The protein, known as tropomyosin-3 (TPM3), is vital for skeletal muscle development…
Cause of mitochondrial dysfunction discovered by Perkins researchers
By leafcutter_admin | Disease Area, Lab, Mitochondrial disease, Mitochondrial Medicine and Biology, Molecular Medicine, News & Events, Research, Research AreaThe disease, known as Leigh Syndrome, has previously been linked to a genetic mutation, but Perkins researchers were able to determine how the mutation led to mitochondrial dysfunction. Mitochondria are…
Groundbreaking discovery on the process of vertebrate development
By leafcutter_admin | Epigenetics and Genomics Laboratory, Lab, Molecular Medicine, News & Events, Research, Research AreaProfessor Ryan Lister and Dr Ozren Bogdanovic from the Perkins Epigenetics and Genomics Laboratory led the study, which has been published in in the prestigious journal Nature Genetics. Their work is focused on…